VISDB Viral Integration Site DataBase

VIS ID

TVIS10015055

Fusion event

HBV-ROCK1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein

Start

1757

Orient

-

Integrated sequence

AAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTA| |GGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGT

Chromosome

chr18

Cytoband

p11.32

Reference genome

Start

End

109965/109965 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-146a-5p ; hsa-mir-584-5p ; hsa-mir-124-3p ; hsa-mir-1280 ; hsa-mir-148b-3p ; hsa-mir-335-5p ; hsa-mir-148a-3p ; hsa-mir-135a-5p ; hsa-mir-145-5p ; hsa-mir-340-5p ; hsa-mir-4662a-5p ; hsa-mir-4753-5p ; hsa-mir-6507-5p ; hsa-mir-6768-3p ; hsa-mir-548aw ; hsa-mir-5093 ; hsa-mir-1468-3p ; hsa-mir-548x-5p ; hsa-mir-548g-5p ; hsa-mir-548f-5p ; hsa-mir-548aj-5p ; hsa-mir-3688-3p ; hsa-mir-300 ; hsa-mir-506-3p ; hsa-mir-584-3p ; hsa-mir-126-3p ; hsa-mir-144-5p

Nearest miRNA

hsa-mir-1-2/Downstream/2291;

Nearest TSS

Nearest CpG islands

None/Target, chr18-CpG: 67/Upstream/33938, chr18-CpG: 21/Downstream/2344

Nearest cancer related gene

ROCK1(OG, No orient, 0)

Upstream sequence

tgatgtaactcttgtctatatctgtctactggtggcattgtggcatatttctgcactgatcacccaggtgatggactcttgtcttggatctgcctatggg

Downstream sequence

ggcatagtgacatatctctgcactgatcactcatgtgatgtaacgcttgtctaagctgcgcctaaaggcgaattgtgacagatatctccactgatcaccc