Basic Information
VIS ID
TVIS10015069
Fusion event
HBV-chr4 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2033
Orient
+
Integrated sequence
CTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTC| |TCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAA
Host Sequence
Chromosome
chr4
Cytoband
q28.3
Reference genome
GRCh37/hg19
Start
133161485/132240330 (Hg38)
End
133161485/132240330 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-12113/Upstream/6733023; hsa-mir-1305/Downstream/11103130;
Nearest TSS
ENST00000502981/Upstream/116299; ENST00000513270/Downstream/206905;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/262295, chr4-CpG: 90/Downstream/907677
Upstream sequence
taaagagaggttttgaggtttccaactgtagcaatggatttgtctatgttttcttgcaattctatcagtttctgatattctgttattaggtgcatacata
Downstream sequence
attcttgtcttccttggccacactctaaagaggacattggagagataatacgcttattttttcaggcaaatagcaatctcagcgtgcttcttaatgctag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate