Basic Information
VIS ID
TVIS10015080
Fusion event
HBV-chr13 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S
Start
29
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCA| |AGATCCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTC
Host Sequence
Chromosome
chr13
Cytoband
q32.2
Reference genome
GRCh37/hg19
Start
98711747/98059493 (Hg38)
End
98711747/98059493 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA13D
Nearest miRNA
hsa-mir-1297/Upstream/1632201; hsa-mir-1267/Downstream/149031;
Nearest TSS
ENST00000623511/Upstream/39914; ENST00000600648/Downstream/83069;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/82357, chr13-CpG: 201/Downstream/82651
Nearby gene
LOC105370328(+6819) ;
Upstream sequence
GCCGCCCAGTTCACAGTGCTCCACTCCGTGACCCCAGTGACCCTCAGAGGCAGGCCATGTCTGTGTTGTAAAACTCTCTTcccaccggacccagaagtgg
Downstream sequence
acatctgacccaagctgggccaatcagatttcatctccaggagtttAACCCTGGCCCAGAGAACCCCTGAGGCTTGAGAAGTCTCCAGCTGAGCCCCATG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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