VISDB Viral Integration Site DataBase

VIS ID

TVIS10015081

Fusion event

HBV-SPIRE2 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2

Start

384

Orient

+

Integrated sequence

GGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACCTCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGT| |CTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAA

Chromosome

chr16

Cytoband

q24.3

Reference genome

Start

End

89938586/89872178 (Hg38)

Orient

+

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-6778-3p ; hsa-mir-3137 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-4469 ; hsa-mir-5193 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4532 ; hsa-mir-1247-3p

Nearest miRNA

hsa-mir-11401/Upstream/1155841;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/17465, chr16-CpG: 151/Downstream/846

Upstream sequence

cacagagagggtcagggaactcctccggtcacacagccagcaaTAAGCTAATGTGTAGTGCTTGGTAAGGACGACGGTTGTTCTGGTTCTACGGGGACTC

Downstream sequence

ACACTCCCTATCATGGGGAGACTGGGTTGTAATTCATACAGGAACACTTGGAAATGAAAGCCCACGTTAAAACCCTAAACCACGGcaggtgcagtggctc