VISDB Viral Integration Site DataBase

VIS ID

TVIS10015082

Fusion event

HBV-SPIRE2 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

1907

Orient

+

Integrated sequence

CCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGA| |CATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCA

Chromosome

chr16

Cytoband

q24.3

Reference genome

Start

End

89938642/89872234 (Hg38)

Orient

-

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-6778-3p ; hsa-mir-3137 ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-6747-3p ; hsa-mir-6727-3p ; hsa-mir-4722-3p ; hsa-mir-331-3p ; hsa-mir-6810-3p ; hsa-mir-6801-3p ; hsa-mir-4279 ; hsa-mir-6749-3p ; hsa-mir-4469 ; hsa-mir-5193 ; hsa-mir-3934-5p ; hsa-mir-764 ; hsa-mir-125a-3p ; hsa-mir-498 ; hsa-mir-378a-5p ; hsa-mir-6821-3p ; hsa-mir-6790-3p ; hsa-mir-372-5p ; hsa-mir-371a-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-4667-3p ; hsa-mir-1470 ; hsa-mir-4532 ; hsa-mir-1247-3p

Nearest miRNA

hsa-mir-11401/Upstream/1155897;

Nearest TSS

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/17521, chr16-CpG: 151/Downstream/790

Upstream sequence

AGTGCTTGGTAAGGACGACGGTTGTTCTGGTTCTACGGGGACTCACACTCCCTATCATGGGGAGACTGGGTTGTAATTCATACAGGAACACTTGGAAATG

Downstream sequence

AAAGCCCACGTTAAAACCCTAAACCACGGcaggtgcagtggctcacacctgtaatcccagcacttttggagggtgaggtgggcagatcacttgaggtcag