VISDB Viral Integration Site DataBase

VIS ID

TVIS10015092

Fusion event

HBV-chr1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein

Start

1720

Orient

-

Integrated sequence

CGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGT| |TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA

Chromosome

chr1

Cytoband

q21.3

Reference genome

Start

End

153943072/153970596 (Hg38)

Orient

-

Location type

Promoter

Fragile sites / regions

Target gene

CREB3L4 ; SLC39A1

miRNAs that regulate target gene

hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-96-5p ; hsa-mir-877-5p ; hsa-mir-30c-5p ; hsa-mir-6788-3p ; hsa-mir-1231 ; hsa-mir-632 ; hsa-mir-4288 ; hsa-mir-1227-5p ; hsa-mir-642a-5p ; hsa-mir-346 ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6845-5p ; hsa-mir-6762-5p ; hsa-mir-4726-5p ; hsa-mir-4640-5p ; hsa-mir-4515 ; hsa-mir-6781-3p ; hsa-mir-2682-3p ; hsa-mir-3194-5p ; hsa-mir-3655 ; hsa-mir-18a-3p ; hsa-mir-324-3p ; hsa-mir-1913 ; hsa-mir-6758-3p ; hsa-mir-2276-5p ; hsa-mir-6892-3p ; hsa-mir-6877-3p ; hsa-mir-6819-3p

Nearest miRNA

hsa-mir-101-1/Upstream/8176; hsa-mir-1182/Downstream/133925;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/3092, chr1-CpG: 75/Downstream/6640

Nearest cancer related gene

SLC39A1(TSG, No orient, 0)

Upstream sequence

TTGCCCAGGAGGCACCCACTGGCTAGTGCTACAGTGTAGCAGAGGTATCACATTAGATGCCTTCTCAAGGCCGTCTGGGCAGCGTCCAAGGCTGGGTAAA

Downstream sequence

GAGGGGACTATGCTCAGATCACTGTTCCTCCCTTTCCTCTGAAAATTACTCCTTGTACCCAAAAGGCAGGGACCAGGTCCTAGCCTCTCTTCAAATCTGC