Basic Information
VIS ID
TVIS10015099
Fusion event
HBV-LOC730100 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2658
Orient
-
Integrated sequence
TACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCC| |AAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACT
Host Sequence
Chromosome
chr2
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
52295318/52068180 (Hg38)
End
52295318/52068180 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
LOC730100
Nearest miRNA
hsa-mir-1301/Upstream/1371918; hsa-mir-10b/Downstream/634342;
Nearest TSS
ENST00000437798/Upstream/842605; ENST00000435357/Downstream/304938;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/1039820, chr2-CpG: 118/Downstream/503085
Upstream sequence
atatacaattatatataaattttatataaattatataaattgataaattttatataaaataatGCTTTGTGAACAACCTGCATTGAGGACATTAAAAACA
Downstream sequence
CCAATGCTTATACTTTGTATTTCTTCAACTTGTCTTACTtgatgaatagatgacagacatacttttctcattgttggacttaaatgcttcaaatattcta
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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