NRG1 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015101
Fusion event
HBV-NRG1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2373
Orient
+
Integrated sequence
GTGGATTCGCACTCCTCCAGCTTATAGACCACCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGA| |AGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAG
Host Sequence
Chromosome
chr8
Cytoband
p12
Reference genome
GRCh37/hg19
Start
32314573/32457057 (Hg38)
End
32314573/32457057 (Hg38)
Orient
-
Location type
Intronic
Target gene
NRG1
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-125a-3p
Nearest miRNA
hsa-mir-124-1/Upstream/2499709; hsa-mir-10400/Downstream/8813991;
Nearest TSS
ENST00000518652/Upstream/236015; ENST00000520502/Downstream/91153;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/816227, chr8-CpG: 169/Downstream/90832
Upstream sequence
atatacagttcaaagaaaggagaaagttcttacaattgtgtccggaattggtggattcttggtctcactgacttcaagaataaagctgtggaccctcgcg
Downstream sequence
ggaggcagagattgcagtgagatgagattgtgccattgcactccagcctaagtgacggagtgagactTTCTCaaaaaaataaataaataaataaataaat
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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