Basic Information
VIS ID
TVIS10015104
Fusion event
HBV-chr1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1853
Orient
+
Integrated sequence
ATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTC| |ATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCG
Host Sequence
Chromosome
chr1
Cytoband
p31.1
Reference genome
GRCh37/hg19
Start
80107938/79642253 (Hg38)
End
80107938/79642253 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1L
Nearest miRNA
hsa-mir-101-1/Upstream/2582051; hsa-mir-11399/Downstream/5491541;
Nearest TSS
ENST00000473358/Upstream/317245; ENST00000567886/Downstream/409151;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/635401, chr1-CpG: 24/Downstream/688719
Upstream sequence
ttggcctgttggccaaatttctggcacttgtagcaagctcctgggggaggaggttctggaagaacgcctggctgctgcggttcaggcgtttggaagtttt
Downstream sequence
tgtgtgctggagatgtggctggggtttgtctcacagtggaggcaagtaattgcaactcagaaatacattgctacttggctgcctctactctattattgta
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate