Basic Information
VIS ID
TVIS10015106
Fusion event
HBV-chr3 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp4 precore/core protein
Start
2418
Orient
-
Integrated sequence
CCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGT| |CGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTT
Host Sequence
Chromosome
chr3
Cytoband
q29
Reference genome
GRCh37/hg19
Start
192716260/192998471 (Hg38)
End
192716260/192998471 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-let-7g/Upstream/3168462; hsa-mir-3137/Downstream/2136035;
Nearest TSS
ENST00000440867/Upstream/80310; ENST00000264735/Downstream/178393;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/80293, chr3-CpG: 84/Downstream/242449
Nearby gene
MB21D2(No orient, 80309)
Upstream sequence
AATATTCTCTGGAAAATCTAAAATCATTCTGTTATCCTAACATTTTTATACTATCATCATTTTAGAAAATAAAAGGCCTGCGTTATATACTAGAAAAATT
Downstream sequence
ctgcttccctgactattcctaggctacagccacacctcattgctgccttttcccccagttcaaagcctccttcacatcttccccttgtatctccccacct
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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