Basic Information
VIS ID
TVIS10015109
Fusion event
HBV-chr10 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2051
Orient
-
Integrated sequence
CGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACC| |TCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGAC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
107780218/106020460 (Hg38)
End
107780218/106020460 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1752055; hsa-mir-202/Downstream/4877630;
Nearest TSS
ENST00000439456/Upstream/201263; ENST00000424701/Downstream/119804;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/1377406, chr10-CpG: 100/Downstream/1143562
Nearby gene
LOC105378468(-6480) ;
Upstream sequence
ggcattgagcagggtaagagtgattaggttttaatgggatggtaaggggtgcatgatcagtcactaaggagggagtagaggtgtcttatacttgtgggtt
Downstream sequence
aaggtggggagatacaaggggaggatgtgaaggaggctttgaactggaggaaaaggcggcaatgaggagtggctgtagcccaggaatagtcagggaagca
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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