Basic Information
VIS ID
TVIS10015112
Fusion event
HBV-chr7 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
165
Orient
-
Integrated sequence
TGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAAC| |ATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGA
Host Sequence
Chromosome
chr7
Cytoband
q31.1
Reference genome
GRCh37/hg19
Start
109957462/110317405 (Hg38)
End
109957462/110317405 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-10525/Upstream/7845874; hsa-mir-10399/Downstream/4335940;
Nearest TSS
ENST00000635602/Upstream/720239; ENST00000464835/Downstream/217349;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1746943, chr7-CpG: 68/Downstream/1244618
Upstream sequence
aggcatgagccactgcgcccggccGAGTTTGTTTTGTTTTTAAATTGGTATAAAAGATTTTTGAAAAATTAAGTTAGTGATTAAAAATCGAGACTACAGT
Downstream sequence
CACCAAGGTACGTAAACTCTCAAATTCCAGGATTACATAAGTTTGCAAGCTACTGTGTTCAGACTCAGTCCAAGCTGCCAATTATATTTTATAAGCTGCC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate