Basic Information
VIS ID
TVIS10015113
Fusion event
HBV-chr10 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein
Start
1795
Orient
-
Integrated sequence
CCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAA| |TTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCT
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
107298472/105538714 (Hg38)
End
107298472/105538714 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1270309; hsa-mir-202/Downstream/5359376;
Nearest TSS
ENST00000439456/Upstream/379786; ENST00000424701/Downstream/280483;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/895660, chr10-CpG: 100/Downstream/1625308
Nearby gene
RNU6-463P(-3949) ;
Upstream sequence
aaaattaaagataaagcataaaggtgttgacacataggaaatacttaggaaacactgtttttatttttACATGCGCTAATTATTTCTCTTTGCCCACATA
Downstream sequence
TCTCTGAAGATAACAGTGAAAGGTAATCCAGGGGGAGGAGACATGTACCCAAGCTTGTGGATATGTGTAATTCATCAGGGTAATTGTCTAGGGGGAAAAA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate