Basic Information
VIS ID
TVIS10015114
Fusion event
HBV-chr10 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
345
Orient
+
Integrated sequence
GAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTCCCCAACCTCCAATCACTCACCAACC| |TCTTGTCCTCCAACTTGTCCTGGTTATCGCTGGATGTGTCTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTC
Host Sequence
Chromosome
chr10
Cytoband
q25.1
Reference genome
GRCh37/hg19
Start
107298448/105538690 (Hg38)
End
107298448/105538690 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Nearest miRNA
hsa-mir-107/Upstream/1270285; hsa-mir-202/Downstream/5359400;
Nearest TSS
ENST00000439456/Upstream/379762; ENST00000424701/Downstream/280507;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/895636, chr10-CpG: 100/Downstream/1625332
Nearby gene
RNU6-463P(-3925) ;
Upstream sequence
ctatattaagttgttgctgttgtgaaaattaaagataaagcataaaggtgttgacacataggaaatacttaggaaacactgtttttatttttACATGCGC
Downstream sequence
TAATTATTTCTCTTTGCCCACATATCTCTGAAGATAACAGTGAAAGGTAATCCAGGGGGAGGAGACATGTACCCAAGCTTGTGGATATGTGTAATTCATC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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