VISDB Viral Integration Site DataBase

VIS ID

TVIS10015118

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase;HBVgp4 precore/core protein

Start

2447

End

2998

Orient

+

Integrated sequence

ATGTTAGTATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTACACCAAGACATTATCAAAAAATGTGAACAGTTTGTAGGCCCACTCACAGTTAATGAGAAAAGAAGATTGCAATTGATTATGCCTGCCAGGTTTTATCCAAAGGTTACCAAATATTTACCATTGGATAAGGGTATTAAACCTT

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1292371/1292256 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/228895; hsa-mir-10397/Downstream/17054;

Nearest TSS

Nearest CpG islands

chr5-CpG: 485/Target, None/Upstream, None/Downstream

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

atggaggtggcagttttgactcagcgtaattcccttgagatgcctgcaggctttataaacggcatgttcctcttcactgtgaggaactgtccaccgtgcg

Downstream sequence

GGAGCACTGGGAGCCAAAAGGGGGCTGGAGCGGAGGTTCCTCAACATCAAATCCAGAAAAACAGGGTGGGGACACGGCAGGGCCCAGCAGCACCATCCCC

Target sequence

CTCCTCAACGAAGGAAGCTGGAGCACAAAAAGCAAAACTGGGTTGCATGACGCTTATCTGACTCGGCGTGGTCCACCTGAGCCGCAGCAGGTGTGAggcagctgccgttcgatgggtagggacttccagtcacgcaagacgcagcatttcaagcaacctgctgtaaacaccgccgagttagcaattctgcactgtacacagaaaacggtgttaggagtgccaatctcatgttatatgacttttgccaccataaaa