Fusion event
HBV-TERT integration
Detection method
PCR and Sanger sequencing
Disease
Hepatocellular carcinoma (HCC)
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Integrated sequence
CTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGC
End
1293047/1292932 (Hg38)
miRNAs that regulate target gene
Nearest miRNA
hsa-mir-4635/Upstream/229320; hsa-mir-10397/Downstream/16378;
Nearest cancer related gene
Upstream sequence
aagaaagtaaaacataaaaatttagattctcagcctattcatattggaaaaaatgagaaagcctgttgtggccaagtgactctttgataaggagatttaa
Downstream sequence
CCTTGAAATTGCGAAGAGGATTATAGGTAACCTGCAGGCACCCTCGCCAGAGCGTCTGTGCTTCCAGACACTTCTCCCCATTGCCGGCAACCCGGCTCCA
Target sequence
CCTCAACATCAAATCCAGAAAAACAGGGTGGGGACACGGCAGGGCCCAGCAGCACCATCCCCTGAACACCCACAAACACTGTCCCTTCCTCAGCAGGTGGAGCCATCTGCTGTCCTCTGCTCCCATGTGGCCCTCTTCATACCTAAAGATGGGACCAGGATCTGTGCTGGAGAACAGTCTTATCTCCCTCCCTCTACCCTGTCCTGGCACAATCAACGAACACtttttttttttaaagacagagtttcactcttg
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.