hsa-mir-422a _LIHC.png
TERT _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015119
Fusion event
HBV-TERT integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
Virus Sequence
Virus name
HBV
Reference genome
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
61
End
355
Orient
-
Integrated sequence
CTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGC
Host Sequence
Chromosome
chr5
Cytoband
p15.33
Reference genome
End
1293047/1292932 (Hg38)
Orient
-
Location type
Intronic
Target gene
Nearest miRNA
hsa-mir-4635/Upstream/229320; hsa-mir-10397/Downstream/16378;
Nearest CpG islands
chr5-CpG: 485/Target, None/Upstream, None/Downstream
Nearest cancer related gene
TERT(OG, No orient, 0)
Upstream sequence
aagaaagtaaaacataaaaatttagattctcagcctattcatattggaaaaaatgagaaagcctgttgtggccaagtgactctttgataaggagatttaa
Downstream sequence
CCTTGAAATTGCGAAGAGGATTATAGGTAACCTGCAGGCACCCTCGCCAGAGCGTCTGTGCTTCCAGACACTTCTCCCCATTGCCGGCAACCCGGCTCCA
Target sequence
CCTCAACATCAAATCCAGAAAAACAGGGTGGGGACACGGCAGGGCCCAGCAGCACCATCCCCTGAACACCCACAAACACTGTCCCTTCCTCAGCAGGTGGAGCCATCTGCTGTCCTCTGCTCCCATGTGGCCCTCTTCATACCTAAAGATGGGACCAGGATCTGTGCTGGAGAACAGTCTTATCTCCCTCCCTCTACCCTGTCCTGGCACAATCAACGAACACtttttttttttaaagacagagtttcactcttg
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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