Basic Information
VIS ID
TVIS10015120
Fusion event
HBV-chr19 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2839
Orient
+
Integrated sequence
TAGACACTATTTACACACTCTATGGAAGGCGGGTATATTATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAA| |GATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATCCTCTGGGATTCTTTCCCGACCACCAGTTGGATCCAGCCTTCAGAGCAAACACCGCAAATCCA
Host Sequence
Chromosome
chr19
Cytoband
q12
Reference genome
GRCh37/hg19
Start
30297359/29806452 (Hg38)
End
30297359/29806452 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-10395/Upstream/9407098; hsa-let-7e/Downstream/5316248;
Nearest TSS
ENST00000633603/Upstream/90663; ENST00000586912/Downstream/5446;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/81765, chr19-CpG: 137/Downstream/4936
Nearby gene
CCNE1(No orient, 5541)
Nearest cancer related gene
CCNE1(OG, No orient, 5541)
Upstream sequence
tgattggccaaggccCCTCCCCCATTAAAGTGCAGAGAGGGTGTAGCTTGGAGGAAAATGCTGGACCCTGACAGGAAGGGAGAGGCCAGGGCCTTTGCTA
Downstream sequence
TCCCAGCCCGTGCTCTGTCTTGCAGCTGTGCCTGTCTTCAGAAATCCCAAAATGAGATTTAAATGAAAGCTGAGGGTATGGCAGTCAGACACAGAACAGA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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