VISDB Viral Integration Site DataBase

VIS ID

TVIS10015121

Fusion event

HBV-CCNE1 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

1928

End

2559

Orient

+

Integrated sequence

TGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATTTGGAAGATCCAGCGTCTAGAGACCTAGTAGTCAGTTATGTCAACACTAATATGGG

Chromosome

chr19

Cytoband

q12

Reference genome

Start

End

30299459/29808552 (Hg38)

Orient

-

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-15b-5p ; hsa-mir-503-5p ; hsa-mir-424-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-107 ; hsa-mir-185-5p ; hsa-mir-103a-3p ; hsa-mir-26b-5p ; hsa-mir-26a-5p ; hsa-mir-16-1-3p ; hsa-mir-195-5p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-151a-3p ; hsa-mir-342-5p ; hsa-mir-125b-5p ; hsa-mir-92a-3p ; hsa-mir-383-3p ; hsa-mir-497-5p ; hsa-mir-4524a-5p ; hsa-mir-4694-3p ; hsa-mir-4524b-5p ; hsa-mir-6838-5p ; hsa-mir-7-5p ; hsa-mir-4477a ; hsa-mir-524-5p ; hsa-mir-520d-5p ; hsa-mir-5191 ; hsa-mir-646 ; hsa-mir-25-5p ; hsa-mir-30c-2-3p ; hsa-mir-144-5p ; hsa-mir-892b

Nearest miRNA

hsa-mir-10395/Upstream/9408529; hsa-let-7e/Downstream/5314148;

Nearest TSS

Nearest CpG islands

None/Target, chr19-CpG: 112/Upstream/83196, chr19-CpG: 137/Downstream/2836

Nearest cancer related gene

CCNE1(OG, No orient, 0)

Upstream sequence

CTTCCCCCTTGCAATCCCTTGGTCTTCCTTCTCCTTAACCTTTATGTCCTGGTGCCCGTCCTCCATCATCAGAGCCTGAACCATATAGGAAGCTAAGCAA

Downstream sequence

aaaatgaaaacaaaaGACATCAGTGGTTTCTGAAGActccaagctgctgtataggctgtgtctgccatcttggacacaacttttctattgttcctattaa

Target sequence

ATAACCCCCAAATCTCTTTATGagtaataacaacacaaattgagcagttaccttgtgccagatactgttgaaaacacttgaggggtattaatacatttacccctcaccgcaaccccatgacgttgggacaattagaattatacccattttacagatgagaagattaaagcacagagaggttggagaaccttcccaaagtctcatagcAAAGGGGAGGTGTTGCCCTCCCTACACAGCAGCTGGTTCACCACCTCT