Basic Information
VIS ID
TVIS10015122
Fusion event
HBV-LOC105375027 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
1325
Orient
-
Integrated sequence
CCATCAGCGCATGCGTGGAACCTTTTCGGCTCCTCTGCCGATCCATACTGCGGAACTCCTAGCCGCTTGTTTTGCTCGCAGCAGGTCTGGAGCAAACATT| |ATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTG
Host Sequence
Chromosome
chr6
Cytoband
p21.31
Reference genome
GRCh37/hg19
Start
33827924/33860147 (Hg38)
End
33827924/33860147 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA6H
Target gene
LOC105375027
Nearest miRNA
hsa-mir-1236/Upstream/161913; hsa-mir-10398/Downstream/38988;
Nearest TSS
ENST00000381078/Upstream/56136; ENST00000526556/Downstream/32603;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/70918, chr6-CpG: 21/Downstream/168014
Upstream sequence
AGGCTCAGAAGAAGGACGGGAAGAAGCGCAAGCGCAGCCGCAAGGAGAGCTATTCAGTGTATGTGTACAAGGTGCTGAAGCAGGTCCATCCCGACACCGG
Downstream sequence
GGCCCTCATCCTACGACCACCTCACATAGGGCTGCTGCACAAGCCACATGGAGGGGCATGGGCCAGGGCCTGCCGAACCTGCAACCCTGCTCCCCACCCT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate