Basic Information
VIS ID
TVIS10015123
Fusion event
HBV-chr18 integration
Validated
Yes
Detection method
PCR and Sanger sequencing
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Good
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
675
End
791
Orient
+
Integrated sequence
AGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTT
Host Sequence
Chromosome
chr18
Cytoband
p11.32
Reference genome
GRCh37/hg19
Start
107267/107267 (Hg38)
End
107919/107919 (Hg38)
Orient
+
Location type
Promoter
Nearest miRNA
hsa-mir-1-2/Downstream/4337;
Nearest TSS
ENST00000575820/Upstream/33722; ENST00000580410/Downstream/50464;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/31240, chr18-CpG: 21/Downstream/4390
Nearby gene
MIR8078(+1798) ;
Upstream sequence
caggggctttgtgacatatctctgcactgatcacccaggtgatgggacttttgtctaggctctgtctacgggggcattgtgacatatctctacactgatc
Downstream sequence
gggcattgtgacagatctctgcactgatcactcaggtgatgtaactattgtctaggctctgcttaaaggggccttgtcacatatgtctgcactgatcacc
Target sequence
acccaggtgatgtaactcttgtgttggatctgcctatgggggcattgagacatatttctgcactgatcacccaggtgatgtaacacttgtgttggatctgcctataggggcattgtgacatatttctgcactgatcacccaggtgatgggactcttgtctaggctctgtgtatgggggctttctgacatatctctgcactgatcacccaggtgatgtaacgcttgactaggctctgcctacggggcacagtgaca
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate