Basic Information
VIS ID
TVIS10015127
Fusion event
HBV-RIDA integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S1/pre-S2/S
Start
3184
Orient
-
Integrated sequence
CAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCCTCAGGCCATGCAGTGG| |
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99118919/98106691 (Hg38)
End
99118919/98106691 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
RIDA
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-375
Nearest miRNA
hsa-mir-12123/Upstream/3033695; hsa-mir-10400/Downstream/286954;
Nearest TSS
ENST00000518652/Upstream/60; ENST00000522319/Downstream/10419;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/41675, chr8-CpG: 37/Downstream/10515
Upstream sequence
gagtatatccttctaggcttttatttgtgtgtgcatgtgcatatctTCAATGCCATTTTTAAAAGTTTCTCTTATACAggcttgctttgttggttagaga
Downstream sequence
ATTTGACTTCAAAGGGTTCTTTTTCCTTTTTCTCAAAAAAACAATATTAGTAAATTATATAACAGTTGGAGACACTGGCTTCTGGAAAAACATTTATCTT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate