Basic Information
VIS ID
TVIS10015132
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2454
Orient
+
Integrated sequence
ACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAG| |TATTCCTTGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATA
Host Sequence
Chromosome
chr8
Cytoband
p11.21
Reference genome
GRCh37/hg19
Start
42501977/42646834 (Hg38)
End
42501977/42646834 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-124-1/Upstream/986326; hsa-mir-10400/Downstream/249363;
Nearest TSS
ENST00000518652/Upstream/100406; ENST00000531610/Downstream/50542;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/104782, chr8-CpG: 63/Downstream/195892
Nearby gene
CHRNB3
Upstream sequence
AACTATAGATCCATGAGGCTGGGTGCAAATTCTGTTTTTCATCATTGTATCACCTTGCAGTGCTGGGTGCTCAATTATCACTGTTGAAGATTTTGGAGGT
Downstream sequence
cgaaaattagctgggcgtggtggtgggtgtctgtaatcccacctactcaggaggctgaggtaggagaatcgcttgaacctgggaggcagaggttgcagtg
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate