Basic Information
VIS ID
TVIS10015136
Fusion event
HBV-RIDA integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S1/pre-S2/S
Start
3025
Orient
-
Integrated sequence
ACACCGCAAATCCAGATTGGGACTTCAATCCCAACAAGGACACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACC| |GCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCATACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGG
Host Sequence
Chromosome
chr8
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
99119078/98106850 (Hg38)
End
99119078/98106850 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA8B
Target gene
RIDA
miRNAs that regulate target gene
hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-375
Nearest miRNA
hsa-mir-12123/Upstream/3033854; hsa-mir-10400/Downstream/286795;
Nearest TSS
ENST00000518652/Upstream/219; ENST00000522319/Downstream/10260;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/41834, chr8-CpG: 37/Downstream/10356
Upstream sequence
TTTGAGCTTACTTTCTCTTTTCTCTAAGGTCAAGTAAAAAATGTGAGACGTTTTCATATACCACAAAGGTAATACAGCAGGCTGGAGTCACTCTAATCAA
Downstream sequence
TGTCTTTTAAAATAATCTTCTAAATAGGTAATACATGGATATGGCAACAACAACAACAAAAAAACTCAAAAGCTATTAAAAAAGCATATACCGTGTAAAG
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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