Basic Information
VIS ID
TVIS10015139
Fusion event
HBV-chr8 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2010
Orient
+
Integrated sequence
CGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCT| |CTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTA
Host Sequence
Chromosome
chr8
Cytoband
q24.23
Reference genome
GRCh37/hg19
Start
137398209/136385966 (Hg38)
End
137398209/136385966 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1204/Upstream/1581021; hsa-mir-10400/Downstream/4346598;
Nearest TSS
ENST00000518652/Upstream/338919; ENST00000523232/Downstream/103482;
Nearest CpG islands
None/Target, chr8-CpG: 109/Upstream/927867, chr8-CpG: 119/Downstream/2110586
Upstream sequence
CTCTTTCTCTTCTATTTTTCCCTTTAATATTATTCCCTGAAAGGGATTTATTTTATGTTTCTCTCTTGCAGAAATCCTGGACTCACAGATCATTTACTCT
Downstream sequence
atctttgtgttactggactaatagggaaaaatgggtgttaggatgctgactggagtagttgatcccaataataaagaggaaactgggtagctgctacaca
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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