Basic Information
VIS ID
TVIS10015146
Fusion event
HBV-chrX integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1815
Orient
+
Integrated sequence
ACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACC| |ATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACC
Host Sequence
Chromosome
chrX
Reference genome
GRCh37/hg19
Start
145124063/145124063 (Hg38)
End
145124063/145124063 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRAXA
Nearest miRNA
hsa-let-7f-2/Upstream/4197832; hsa-mir-105-1/Downstream/868687;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/1488937, chrX-CpG: 63/Downstream/506840
Upstream sequence
TGAGGAACATTTACATTTCTAAATATTTGTTTTAATATAACTCCAAGTATATTTTAAATCTAATTTTCTTTTTTAGAAACAGAGTTCATTTAGTAGGCTA
Downstream sequence
cagcacgttgggaggccgaggcgggcagatcacaaggtcaggagaccgagaccatcctggctaacacggtgaaaccccgtctctactaaaaatacaaaaa
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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