VISDB Viral Integration Site DataBase

VIS ID

TVIS10015153

Fusion event

HBV-ETFDH integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1824

Orient

-

Integrated sequence

TTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTT| |TTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAG

Chromosome

chr4

Cytoband

q32.1

Reference genome

Start

End

159603238/158682086 (Hg38)

Orient

+

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-3127-5p ; hsa-mir-8485 ; hsa-mir-6754-5p ; hsa-mir-4441 ; hsa-mir-4270 ; hsa-mir-211-3p ; hsa-mir-1247-3p ; hsa-mir-1976 ; hsa-mir-3653-5p ; hsa-mir-4279 ; hsa-mir-4532 ; hsa-mir-4722-3p ; hsa-mir-498 ; hsa-mir-5001-3p ; hsa-mir-5571-5p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6778-3p ; hsa-mir-6787-3p ; hsa-mir-6791-3p ; hsa-mir-6814-5p ; hsa-mir-6829-3p ; hsa-mir-6836-3p ; hsa-mir-329-3p ; hsa-mir-362-3p ; hsa-mir-369-3p ; hsa-mir-374c-5p ; hsa-mir-3941 ; hsa-mir-577 ; hsa-mir-603 ; hsa-mir-655-3p

Nearest miRNA

hsa-mir-12113/Upstream/6145570; hsa-mir-1305/Downstream/446716;

Nearest TSS

Nearest CpG islands

None/Target, chr4-CpG: 46/Upstream/9651, chr4-CpG: 53/Downstream/40910

Upstream sequence

caactgacaaggatattcgattttttctgtgggatacaacatttatttatttatttatttatttagagacagagtctcgctctgttgcccatgctggagt

Downstream sequence

AATTTCCATAAATAATACTCTAAAGCACAGTGGATATTTTTTAACTGTCATGTGATTTATCATGTGATTATTGGGTTATATTAATCCCAGAATTTTTATT