Basic Information
VIS ID
TVIS10015154
Fusion event
HBV-chr10 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
780
Orient
-
Integrated sequence
ACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATC| |TTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTAAACCCTAACAAAACAAAGAGATGGGGTTACTCTCTAAATTTTAT
Host Sequence
Chromosome
chr10
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
42400656/41839551 (Hg38)
End
42400656/41839551 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1265/Upstream/6198299; hsa-mir-107/Downstream/1158012;
Nearest TSS
ENST00000439456/Upstream/3386370; ENST00000442306/Downstream/345788;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/2896445, chr10-CpG: 184/Downstream/271482
Upstream sequence
caaaggaagaaaaggaaatatcttcgtataaaaactagacagaatcattctcagaaactactttgtgatgtgtgcgttcaactcacagagtttaagcttt
Downstream sequence
cttttcatagagcagtttggaaacactctgtttgtaaagtctgcaagtggatatttggacctctttgaggccttcgctggaaacgggatttcttcatatc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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