Basic Information
VIS ID
TVIS10015159
Fusion event
HBV-LOC107984536 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1831
Orient
-
Integrated sequence
CTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACC| |TCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGG
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
84442929/84049150 (Hg38)
End
84442929/84049150 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA12B
Target gene
LOC107984536
Nearest miRNA
hsa-let-7i/Upstream/2890689; hsa-mir-1178/Downstream/2695918;
Nearest TSS
ENST00000382841/Upstream/387431; ENST00000642846/Downstream/105188;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1361283, chr12-CpG: 17/Downstream/862271
Upstream sequence
GACAACAACTTTGAGTGAATACTTCTCTATGATGAAGCACGAGTTTTTATTACTCCTCTGCCGGTAGATAGGGTAGGGTGAGACATCCAcagagatggcg
Downstream sequence
atgaataatttaaataaatttcttacttaaatgtcacagcaatcttttcaggaataaatacttcccattcccatttaatatgaggaatgaggTACTCTTC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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