VISDB Viral Integration Site DataBase

VIS ID

TVIS10015160

Fusion event

HBV-MSI1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2

Start

220

Orient

+

Integrated sequence

TCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACATCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGT| |TGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGACTTCTCTCAATTTTCTAGGGGGAACTACCGTGTGTCTTGGCCAAAATTCGCAGTC

Chromosome

chr12

Cytoband

q24.31

Reference genome

Start

End

120812093/120374290 (Hg38)

Orient

+

Location type

Promoter

Fragile sites / regions

FRA12E ; FRA12C

Target gene

miRNAs that regulate target gene

hsa-mir-197-3p ; hsa-let-7b-5p ; hsa-mir-4697-5p ; hsa-mir-4488 ; hsa-mir-6825-5p ; hsa-mir-1237-5p ; hsa-mir-6883-5p ; hsa-mir-6785-5p ; hsa-mir-4728-5p ; hsa-mir-604 ; hsa-mir-149-3p ; hsa-mir-4467 ; hsa-mir-8072 ; hsa-mir-3960 ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-6836-5p ; hsa-mir-6132 ; hsa-mir-6805-5p ; hsa-mir-1205 ; hsa-mir-3196 ; hsa-mir-6816-5p ; hsa-mir-3180-3p ; hsa-mir-3180 ; hsa-mir-5572 ; hsa-mir-4260 ; hsa-mir-450a-2-3p ; hsa-mir-6763-5p ; hsa-mir-6857-5p ; hsa-mir-6810-5p ; hsa-mir-3150a-3p ; hsa-mir-2110 ; hsa-mir-939-5p ; hsa-mir-1343-5p ; hsa-mir-3175 ; hsa-mir-4719 ; hsa-mir-502-3p ; hsa-mir-501-3p ; hsa-mir-137 ; hsa-mir-330-3p

Nearest miRNA

hsa-let-7i/Upstream/218791; hsa-mir-3612/Downstream/348903;

Nearest TSS

Nearest CpG islands

None/Target, chr12-CpG: 104/Upstream/4734, chr12-CpG: 33/Downstream/23493

Nearest cancer related gene

MSI1(OG, No orient, 0)

Upstream sequence

acattctatgggtttgggcaaatgtataaggacatgtatctcccattatactgtcatacagagtagtttcactgtcctaaacattctctgtgctccacct

Downstream sequence

atttgttctcccctcccccaacccctgacaacccctgatctttcactctccatagttttctcttttcaagaatgtcatataggccggacgcggtggctca