VISDB Viral Integration Site DataBase

VIS ID

TVIS10015162

Fusion event

HBV-SENP5 integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp4 precore/core protein

Start

1694

End

1901

Orient

-

Integrated sequence

ACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGC

Chromosome

chr3

Cytoband

q29

Reference genome

Start

End

196625719/196898848 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-let-7d-5p ; hsa-mir-6516-5p ; hsa-mir-455-3p ; hsa-mir-4763-3p ; hsa-mir-1207-5p ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-6499-3p ; hsa-mir-6722-3p ; hsa-mir-1909-3p ; hsa-mir-4537 ; hsa-mir-1827 ; hsa-mir-940 ; hsa-mir-6893-5p ; hsa-mir-6808-5p ; hsa-mir-193b-3p ; hsa-mir-193a-3p ; hsa-mir-1273h-5p ; hsa-mir-149-3p ; hsa-mir-30b-3p ; hsa-mir-3192-5p ; hsa-mir-3689a-3p ; hsa-mir-3689b-3p ; hsa-mir-3689c ; hsa-mir-4728-5p ; hsa-mir-490-3p ; hsa-mir-6779-5p ; hsa-mir-6780a-5p ; hsa-mir-6785-5p ; hsa-mir-6799-5p ; hsa-mir-6883-5p ; hsa-mir-7106-5p ; hsa-mir-7851-3p

Nearest miRNA

hsa-let-7g/Upstream/1016358; hsa-mir-4797/Downstream/395030;

Nearest TSS

Nearest CpG islands

None/Target, chr3-CpG: 148/Upstream/30138, chr3-CpG: 130/Downstream/42976

Upstream sequence

tggaagttaacagtaacaaaatagtcatttatgtgaaaaccctaaccaaaatgaagtcagagagggccatgaagaagaagctgtcagacgtgatttcctg

Downstream sequence

ttccattcaattccgttcaatgattccattagattccatttgatgatgattccattcgtctctactaaaaatacaaaaaaattagccgggcgtggtggca

Target sequence

ccattcgattctatgcgatgattccattccattccattggaagatgattccattcgagaccattcgatgattgcattcaattcattcgatgacga