GLS2 _LIHC.png
Expression analysis of TCGA samples
Basic Information
VIS ID
TVIS10015169
Fusion event
HBV-GLS2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S1/pre-S2/S
Start
3066
Orient
+
Integrated sequence
ACCTGGCCAGACGCCAACAAGGTAGGAGCTGGAGCATTCGGGCTGGGTTTCACCCCACCGCACGGAGGCCTTTTGGGGTGGAGCCCTCAGGCTCAGGGCA| |TACTACAAACTTTGCCAGCAAATCCGCCTCCTGCCTCCACCAATCGCCAGTCAGGAAGGCAGCCTACCCCGCTGTCTCCACCTTTGAGAAACACTCATCC
Host Sequence
Chromosome
chr12
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
56869742/56475958 (Hg38)
End
56869742/56475958 (Hg38)
Orient
+
Location type
Intronic
Target gene
GLS2
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-16-5p
Nearest miRNA
hsa-mir-1244-3/Upstream/2138644; hsa-let-7i/Downstream/718546;
Nearest TSS
ENST00000382841/Upstream/3486; ENST00000639027/Downstream/1035;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/7314, chr12-CpG: 93/Downstream/11659
Nearest cancer related gene
GLS2(TSG, No orient, 0)
Upstream sequence
TGGGGTTAGAGAGCCACTGGGGCAGCTGGAGAGGACAGCATGCCATGGCGAAATGCAGCCAGGGGCTAAGTAGCAAGGGAACTTACAAAATCAAACTTCT
Downstream sequence
CTGCTTTGTTACAGTCCATCTGCAGAGAAAGAGAGAGATGTCAGCATTCTAAGTGTAGGAGGATGACAGAGGGAAGGGTCAGAAGGATCTAGTGGAGTTC
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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