Basic Information
VIS ID
TVIS10015170
Fusion event
HBV-chr12 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
644
Orient
+
Integrated sequence
GAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTCGGACGGAAATTGCACCTGTATTCCCATCCCATCATCCTGGGCTTTCGGAAAATTCCTATG| |GGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAGTTATATGG
Host Sequence
Chromosome
chr12
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
84251819/83858040 (Hg38)
End
84251819/83858040 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA12B
Nearest miRNA
hsa-let-7i/Upstream/2699579; hsa-mir-1178/Downstream/2887028;
Nearest TSS
ENST00000382841/Upstream/196321; ENST00000642846/Downstream/296298;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/1170173, chr12-CpG: 17/Downstream/1053381
Upstream sequence
tacaggtggtctatatggatgggtacaggtgtggtggtagaagcaggtttggtggacctgttctcatgcccctaggaggagtgttcaggtaccacctgaa
Downstream sequence
cactggtagtggatagggcagagagagtctcagtcttccagaccatgtgctcaggctctgaggagggtaaaactgggctgggtggggttgttgtcagtga
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate