Basic Information
VIS ID
TVIS10015172
Fusion event
HBV-chr14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1459
Orient
-
Integrated sequence
AATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGATCCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGA| |CCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTGCCGTTCCGACCGACCACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTG
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
42967875/42498672 (Hg38)
End
42967875/42498672 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/5546281; hsa-mir-1185-1/Downstream/5262323;
Nearest TSS
ENST00000550708/Upstream/86099; ENST00000557465/Downstream/1885873;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/891546, chr14-CpG: 22/Downstream/2388797
Upstream sequence
TTTTTTTTTTGAAGGATTTTTGACAATGTATTCAAAAGCAATGTGACTTAGTAGTGATTAAGACCACCACTGACCCAGAGAGAAATATATTAAGAAACAG
Downstream sequence
ATATACCTATtgatatggtttggatctgtgcccccacccaaatctcatgttggattgtaattcccactgttggagatggggcctggcaggaggtgtttag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate