Basic Information
VIS ID
TVIS10015173
Fusion event
HBV-chr1 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Nontumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1620
Orient
-
Integrated sequence
ACGGGGCGCACCTCTCTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCAC| |CGTGAACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGT
Host Sequence
Chromosome
chr1
Cytoband
p32.3
Reference genome
GRCh37/hg19
Start
53886789/53421117 (Hg38)
End
53886789/53421117 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA1B
Nearest miRNA
hsa-mir-12136/Upstream/1584715; hsa-mir-101-1/Downstream/632962;
Nearest TSS
ENST00000473358/Upstream/52872; ENST00000463126/Downstream/38282;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/92961, chr1-CpG: 106/Downstream/17350
Upstream sequence
accactacctctctctactttcaaaactatttttatcaccctggaaaaatacttcatgtccattaaataatcacttcctgcaatggtttgaatgtgtcac
Downstream sequence
ccaaagcttaggcattggaaacttaatcctcaatgcaacggtgttgaggggtgggatctttaagaggtgattaggtcatgagggcagagccctcatggat
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate