Basic Information
VIS ID
TVIS10015184
Fusion event
HBV-chr6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp3 X protein;HBVgp4 precore/core protein
Start
1825
Orient
-
Integrated sequence
TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT| |TTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGA
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
71303876/70594173 (Hg38)
End
71303876/70594173 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/13203961; hsa-mir-10524/Downstream/782787;
Nearest TSS
ENST00000381078/Upstream/27256; ENST00000606298/Downstream/2265;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/26841, chr6-CpG: 90/Downstream/73509
Nearby gene
SDHAF4(No orient, 5269)
Upstream sequence
GGTTAAAATTAAGACTATGCTGTATTCGTGAAAAGCTGGAATTACCATGAATCAGAAAAACACTTCTATATCAGAAAGTATCTATTATTTTAGAACTATA
Downstream sequence
tttgagttgttgctggaataagttaagaccttggggctatgaagatagaataaatgtatttgtatgtgataaggacattagttttggaaggccagTGCCA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate