Basic Information
VIS ID
TVIS10015185
Fusion event
HBV-chr6 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
166
Orient
+
Integrated sequence
GGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGAGGATTGGGGACCCTGCGCTGAACATGGAGAACA| |TCACATCAGGATTCCTAGGACCCCTTCTCGTGTTACAGGCGGGGTTTTTCTTGTTGACAAGAATCCTCACAATACCGCAGAGTCTAGACTCGTGGTGGAC
Host Sequence
Chromosome
chr6
Cytoband
q13
Reference genome
GRCh37/hg19
Start
71303937/70594234 (Hg38)
End
71303937/70594234 (Hg38)
Orient
-
Location type
Intergenic
Fragile sites / regions
FRA6D
Nearest miRNA
hsa-mir-10398/Upstream/13204022; hsa-mir-10524/Downstream/782726;
Nearest TSS
ENST00000381078/Upstream/27317; ENST00000606298/Downstream/2204;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/26902, chr6-CpG: 90/Downstream/73448
Nearby gene
SDHAF4(No orient, 5330)
Upstream sequence
tctaaaatttgtatagtataaataataaatcatttgtttgtcaaataagtgcaaaatttctcccaAGTTTAAATATCTCTCAGTATTTATTTGTAATACA
Downstream sequence
gtatgtgataaggacattagttttggaaggccagTGCCAGTGCCAGAAtgctatagtttgaatgtttgtctcctccaaaactcgtgttaaactttatccc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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