VISDB Viral Integration Site DataBase

VIS ID

TVIS10015188

Fusion event

HBV-EMSY integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp1 Polymerase

Start

2777

Orient

-

Integrated sequence

CCATTGGATAAGGGTATTAAACCTTATTATCCAGAACATCTAGTTAATCATTACTTCCAAACTAGACACTATTTACACACTCTATGGAAGGCGGGTATAT| |TATATAAGAGAGAAACAACACATAGCGCCTCATTTTGTGGGTCACCATATTCTTGGGAACAAGATCTACAGCATGGGGCAGAATCTTTCCACCAGCAATC

Chromosome

chr11

Cytoband

q13.5

Reference genome

Start

End

76246842/76535798 (Hg38)

Orient

+

Location type

Intronic

Fragile sites / regions

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-657 ; hsa-mir-329-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-93-5p ; hsa-mir-106a-5p ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-519d-3p ; hsa-mir-17-5p ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p

Nearest miRNA

hsa-mir-10392/Upstream/1200612; hsa-let-7a-2/Downstream/2866224;

Nearest TSS

Nearest CpG islands

None/Target, chr11-CpG: 30/Upstream/90015, chr11-CpG: 92/Downstream/134607

Nearest cancer related gene

EMSY(OG, No orient, 0)

Upstream sequence

tgagtgaatgaataagtgaatTCAGAAGTGAAAGACATTATGCCTTCTAGGGGCTTATAGTCTTCTTGGGGAGATAAAGCATGAAGTTTACAATAAATAG

Downstream sequence

AAAGATAAGCAAACAGACAAAAAAATTGTTTGTTTTTTTTTTTTTAAGAGAAACTTTGTTTATAGGGTTTGTTTTTTTTTAACTAATATAAAACAGATTC