Basic Information
VIS ID
TVIS10015192
Fusion event
HBV-chr14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2028
Orient
+
Integrated sequence
TGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTA| |GAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCAATTCTTTGCTGGGGGGAACTAATGACTCTAGCTACCTGGGTGGGTGTTAATT
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
42989009/42519806 (Hg38)
End
42989009/42519806 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/5567415; hsa-mir-1185-1/Downstream/5241189;
Nearest TSS
ENST00000550708/Upstream/107233; ENST00000557465/Downstream/1864739;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/912680, chr14-CpG: 22/Downstream/2367663
Upstream sequence
aaaagaaaatttccagcgaattgcactctacccacaaagttgtctttcagaattgagatagaaatgaaaactttgaggaagtaaacaaagagaaataaaa
Downstream sequence
actaagggagctcattaccactaggtctcccttacaggaagggctaatgagagttccttacctgaaaaaaaggccactaattaataacataaaacttaag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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