Basic Information
VIS ID
TVIS10015193
Fusion event
HBV-chr14 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
484
Orient
+
Integrated sequence
CTGCGGCGTTTTATCATCTTCCTCTTCATCCTGCTGCTATGCCTCATCTTCTTGTTGGTTCTTCTGGACTATCAAGGTATGTTGCCCGTTTGTCCTCTAA| |TTCCAGGATCCTCAACAACCAGCACGGGACCATGCCGGACCTGCATGACTACTGCTCAAGGAACCTCTATGTATCCCTCCTGTTGCTGTACCAAACCTTC
Host Sequence
Chromosome
chr14
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
42989246/42520043 (Hg38)
End
42989246/42520043 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-208a/Upstream/5567652; hsa-mir-1185-1/Downstream/5240952;
Nearest TSS
ENST00000550708/Upstream/107470; ENST00000557465/Downstream/1864502;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/912917, chr14-CpG: 22/Downstream/2367426
Upstream sequence
ttattcagcacaatctaggactgtaaagtatttttagacctagtatgagggtgaaataacaacattattaacaactattgctaatataatcaagggatac
Downstream sequence
ttactataaaattatgtaaatttacacatcaaaaacataaaatgaggaggcggtaaaagtataaggttgtcgtatataatcaaggttaagttgttatcag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate