VISDB Viral Integration Site DataBase

VIS ID

TVIS10015195

Fusion event

HBV-PBX1 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein

Start

1725

Orient

+

Integrated sequence

ACGCCCACCAAATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTT| |TAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTT

Chromosome

chr1

Cytoband

q23.3

Reference genome

Start

End

164826273/164857036 (Hg38)

Orient

+

Location type

Intronic

Target gene

miRNAs that regulate target gene

hsa-mir-124-3p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-149-5p ; hsa-mir-196b-5p ; hsa-mir-198 ; hsa-mir-1247-3p ; hsa-mir-3074-5p ; hsa-mir-4722-3p ; hsa-mir-617 ; hsa-mir-6505-3p ; hsa-mir-6727-3p ; hsa-mir-6747-3p ; hsa-mir-6882-3p

Nearest miRNA

hsa-mir-101-1/Upstream/2514396; hsa-mir-1182/Downstream/1050885;

Nearest TSS

Nearest CpG islands

None/Target, chr1-CpG: 111/Upstream/280356, chr1-CpG: 29/Downstream/260483

Nearest cancer related gene

PBX1(OG, No orient, 0)

Upstream sequence

CCACACATACTTGAATCCCAGCTCTGCTACTGCCAGGTTCTTCCTGATGCcacttctgacaacagatgagaagttttcttccaattccccaaaaccaact

Downstream sequence

aggtgtcctacaatccaactcaattctgacaccaactacccggaattagcttcagactcctaaggtttaagggctcagtcccacaagcctgccctcacat