Basic Information
VIS ID
TVIS10015200
Fusion event
HBV-chr21 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S;HBVgp2
Start
736
Orient
-
Integrated sequence
TTCCTATGGGAGTGGGCCTCAGCCCGTTTCTCCTGGCTCAGTTTACTAGTGCCATTTGTTCAGTGGTTCGTAGGGCTTTCCCCCACTGTTTGGCTTTCAG| |TTATATGGATGATGTGGTATTGGGGGCCAAGTCTGTACAGCATCTTGAGTCCCTTTTTACCGCTGTTACCAATTTTCTTTTGTCTTTGGGTATACATTTA
Host Sequence
Chromosome
chr21
Cytoband
p11.2
Reference genome
GRCh37/hg19
Start
11132385/10380070 (Hg38)
End
11132385/10380070 (Hg38)
Orient
+
Nearest miRNA
hsa-mir-10396a/Upstream/1392405; hsa-let-7c/Downstream/3026314;
Nearest TSS
ENST00000624081/Upstream/37333; ENST00000612957/Downstream/141483;
Nearest CpG islands
None/Target, chr21-CpG: 261/Upstream/261130, chr21-CpG: 27/Downstream/25406
Upstream sequence
aaaTAggccaggtgcagtggctcacacctgtaatcccagcactttgggagtccgaggtgggtgtatcacgaggtcaggagatcaagaccgacctggccaa
Downstream sequence
catggtgaaaccccatctctactaaaaaaacaaatacaaaatattagccgggcgtggtggcaggtgcctgtcaacccagctactcaggaggctgaggcag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate