VISDB Viral Integration Site DataBase

VIS ID

TVIS10015203

Fusion event

HBV-ASTN2 integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein

Start

1635

Orient

-

Integrated sequence

CTTTACGCGGACTCCCCGTCTGTGCCTTCTCATCTGCCGGACCGTGTGCACTTCGCTTCACCTCTGCACGTCGCATGGAGACCACCGTGAACGCCCACCA| |AATATTGCCCAAGGTCTTACATAAGAGGACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGG

Chromosome

chr9

Cytoband

q33.1

Reference genome

Start

End

119720873/116958594 (Hg38)

Orient

-

Location type

Intronic

Fragile sites / regions

FRA9E ; FRA9B

Target gene

miRNAs that regulate target gene

hsa-mir-26b-5p ; hsa-mir-526b-5p ; hsa-mir-1253 ; hsa-mir-591 ; hsa-mir-6761-5p ; hsa-mir-5571-5p ; hsa-mir-6880-5p ; hsa-mir-8085 ; hsa-mir-6746-5p ; hsa-mir-6731-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-765 ; hsa-mir-6077 ; hsa-mir-766-5p ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6760-5p ; hsa-mir-4419a ; hsa-mir-4779 ; hsa-mir-6891-5p ; hsa-mir-3173-3p ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-6770-5p ; hsa-mir-124-5p ; hsa-mir-6867-5p ; hsa-mir-5195-5p ; hsa-mir-8485 ; hsa-mir-5010-3p ; hsa-mir-2113 ; hsa-mir-6738-3p ; hsa-mir-544a ; hsa-mir-6071 ; hsa-mir-6828-3p ; hsa-mir-3152-3p ; hsa-mir-1251-3p

Nearest miRNA

hsa-let-7a-1/Upstream/2749065; hsa-mir-12126/Downstream/3286385;

Nearest TSS

Nearest CpG islands

None/Target, chr9-CpG: 64/Upstream/271106, chr9-CpG: 163/Downstream/454381

Upstream sequence

tcttggatgctgagtaaactcagtctgtcatttacctatgaaaacaacagttcagttcctcacttaaatgtacacagacaagccaaattgagattaattt

Downstream sequence

aaacaaacaaaaaaaaGAGCCGACATCTggcctcctggaagaagagatgtttaaactgaggccaaaaggatgagtaggaatAGCCCTAGTCACTGGAAAT