VISDB Viral Integration Site DataBase

VIS ID

TVIS10015209

Fusion event

HBV-TERT integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein

Start

1762

Orient

-

Integrated sequence

GACTCTTGGACTCTCAGCAATGTCAACGACCGACCTTGAGGCATACTTCAAAGACTGTTTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTA| |AAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTAC

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1299589/1299474 (Hg38)

Orient

-

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/236500; hsa-mir-10397/Downstream/9836;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/3619, chr5-CpG: 18/Downstream/35488

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

ATCAAAACTGGCAGAGAAGACATTTAGCAAATCATGAACAAAGGCACTGCGGAACTGGAGAGAGGCCGCGCAGTCAAACGTGAGCAGGTGCCTGAATGCA

Downstream sequence

CTTCAACGCATGTGAGTGTTGGGGAAGGAGACAGACACCCCATGTGAGGAGGAACCGTGCGAGCTACGTCGCTGAGACAAGACACAGTGGGACAGGTGAG