VISDB Viral Integration Site DataBase

VIS ID

TVIS10015210

Fusion event

HBV-TERT integration

Validated

No

Detection method

WGS

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Normal

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1820

Orient

+

Integrated sequence

TTGTTTAAAGACTGGGAGGAGTTGGGGGAGGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCA| |ACTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTAT

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1299592/1299477 (Hg38)

Orient

+

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/236503; hsa-mir-10397/Downstream/9833;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/3622, chr5-CpG: 18/Downstream/35485

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

AGAGGCCGCGCAGTCAAACGTGAGCAGGTGCCTGAATGCAGCAGCTGTCGCAGCCTGGCATGGCCCAGCTCAGATTTCGCCAAGGCACACAGCTCATCAT

Downstream sequence

CAACGCATGTGAGTGTTGGGGAAGGAGACAGACACCCCATGTGAGGAGGAACCGTGCGAGCTACGTCGCTGAGACAAGACACAGTGGGACAGGTGAGACA