VISDB Viral Integration Site DataBase

VIS ID

TVIS10015211

Fusion event

HBV-TERT integration

Validated

Yes

Detection method

PCR and Sanger sequencing

Data source

Curated

Sample type

Disease

Hepatocellular carcinoma (HCC)

Quality evaluation

Good

Reported year

2012

PubMed ID

Virus name

HBV

Reference genome

Region type

HBVgp3 X protein;HBVgp4 precore/core protein

Start

1821

End

2427

Orient

+

Integrated sequence

CTTTTTCACCTCTGCCTAATCATCTCTTGTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACTCTCGTTTTTGCCTTCTGACTTCTTTCCTTCAGTACGAGATCTTCTAGATACCGCCTCAGCTCTGTATCGGGAAGCCTTAGAGTCTCCTGAGCATTGTTCACCTCACCATACTGCACTCAGGCAAGCA

Chromosome

chr5

Cytoband

p15.33

Reference genome

Start

End

1299609/1299494 (Hg38)

Orient

-

Location type

Promoter

Target gene

miRNAs that regulate target gene

hsa-mir-138-5p ; hsa-mir-498 ; hsa-mir-193b-3p ; hsa-mir-335-5p ; hsa-mir-512-5p ; hsa-mir-1207-5p ; hsa-mir-1266-5p ; hsa-mir-1182 ; hsa-mir-181a-5p ; hsa-mir-6776-3p ; hsa-mir-197-3p ; hsa-mir-6740-3p ; hsa-mir-6760-3p ; hsa-mir-532-5p ; hsa-mir-3064-5p ; hsa-mir-422a ; hsa-mir-346 ; hsa-mir-1226-3p ; hsa-mir-1255a ; hsa-mir-1255b-5p ; hsa-mir-143-3p ; hsa-mir-3161 ; hsa-mir-3605-5p ; hsa-mir-3620-3p ; hsa-mir-3682-3p ; hsa-mir-4323 ; hsa-mir-4712-3p ; hsa-mir-4733-3p ; hsa-mir-4758-3p ; hsa-mir-4770 ; hsa-mir-6088 ; hsa-mir-7112-3p

Nearest miRNA

hsa-mir-4635/Upstream/235877; hsa-mir-10397/Downstream/9816;

Nearest TSS

Nearest CpG islands

None/Target, chr5-CpG: 87/Upstream/2996, chr5-CpG: 18/Downstream/35468

Nearest cancer related gene

TERT(OG, No orient, 0)

Upstream sequence

GATCAAAACTGGCAGAGAAGACATTTAGCAAATCATGAACAAAGGCACTGCGGAACTGGAGAGAGGCCGCGCAGTCAAACGTGAGCAGGTGCCTGAATGC

Downstream sequence

GGGGAAGGAGACAGACACCCCATGTGAGGAGGAACCGTGCGAGCTACGTCGCTGAGACAAGACACAGTGGGACAGGTGAGACAGTAGCGCTGGAACACGG

Target sequence

gatggacccgtttgtttaaccagtttgttaaaggacattttagcagggatttccctgctttgtagctattaaaataaaacagcgggggtcggtcgtggacgggagtgtgtacatgatgtgcgtagtcacgtgaattcccagggctgtggggcaaatgtccaggggtgccaatgctgggtcttttgggaagaggatgcttagtgcttgtggaaactgccactctgtgttccagagGGAGGGgggcagaaaagtgct