Basic Information
VIS ID
TVIS10015212
Fusion event
HBV-chr11 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
2304
Orient
+
Integrated sequence
GTGGTTTCACATTTCTTGTCTCACTTTTGGAAGAGAAACAGTTATAGAGTATTTGGTGTCTTTCGGAGTGTGGATTCGCACTCCTCCAGCTTATAGACCA| |CCAAATGCCCCTATCCTATCAACACTTCCGGAGACTACTGTTGTTAGACGACGAGGCAGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGT
Host Sequence
Chromosome
chr11
Cytoband
p15.4
Reference genome
GRCh37/hg19
Start
4676920/4655690 (Hg38)
End
4676920/4655690 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-210/Upstream/799549; hsa-let-7a-2/Downstream/2579076;
Nearest TSS
ENST00000527297/Upstream/12270; ENST00000322110/Downstream/29402;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/47390, chr11-CpG: 32/Downstream/1578848
Nearby gene
OR51E1(No orient, 203)
Upstream sequence
CTGAAGGGCTCAGAAAAGTCTGCTCTTCATCCTATATGCTTACATAAGAGGTATATTTATACCTACATAAGAGGTATAAATTTATCAAAGAAGGAAATAT
Downstream sequence
TTCCTTATGCTAGCATAAGTATCACAAAGTCCTTATTAACCATTATGACATCAAGCGGTGTCTCATACAGGTTTCTATTAATTtgctttggatcacttcc
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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