Basic Information
VIS ID
TVIS10015218
Fusion event
HBV-chr2 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp4 precore/core protein
Start
1849
Orient
+
Integrated sequence
GGAGATTAGGTTAAAGGTCTTTGTACTAGGAGGCTGTAGGCATAAATTGGTCTGCGCACCAGCACCATGCAACTTTTTCACCTCTGCCTAATCATCTCTT| |GTTCATGTCCTACTGTTCAAGCCTCCAAGCTGTGCCTTGGGTGGCTTTGGGGCATGGACATCGACCCTTATAAAGAATTTGGAGCTACTGTGGAGTTACT
Host Sequence
Chromosome
chr2
Cytoband
q13
Reference genome
GRCh37/hg19
Start
110639781/109882204 (Hg38)
End
110639781/109882204 (Hg38)
Orient
+
Location type
Intergenic
Fragile sites / regions
FRA2S
Nearest miRNA
hsa-mir-1285-2/Upstream/568579; hsa-mir-10b/Downstream/187757;
Nearest TSS
ENST00000437798/Upstream/41827; ENST00000482065/Downstream/16224;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/87076, chr2-CpG: 91/Downstream/65311
Nearby gene
LIMS3
Upstream sequence
cacagcacctggctgattccatatctttgctattgtgaataatgctgtgataaacatatgagtgcagttatctttttgatataatgatttcttttccttt
Downstream sequence
gggtagatgcccagttgtggtattgctagattgaatggtagttctattttcagttctccgagaaatctccatactgatttccatagaggttgtactaatt
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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