Basic Information
VIS ID
TVIS10015221
Fusion event
HBV-chr16 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp3 X protein
Start
1405
Orient
+
Integrated sequence
GCAGGTCTGGAGCAAACATTATCGGGACTGATAACTCTGTTGTCCTATCCCGCAAATATACATCGTTTCCATGGCTGCTAGGCTGTGCTGCCAACTGGAT| |CCTGCGCGGGACGTCCTTTGTTTACGTCCCGTCGGCGCTGAATCCTGCGGACGACCCTTCTCGGGGTCGCTTGGGACTCTCTCGTCCCCTTCTCCGTCTG
Host Sequence
Chromosome
chr16
Cytoband
q12.1
Reference genome
GRCh37/hg19
Start
49205999/49172088 (Hg38)
End
49205999/49172088 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/15008415; hsa-mir-11401/Downstream/1120528;
Nearest TSS
ENST00000527434/Upstream/1536; ENST00000564875/Downstream/109394;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/360735, chr16-CpG: 24/Downstream/103124
Nearby gene
LOC102724847(-1726) ;
Upstream sequence
ACCCACACTGTCCTCTGAGACCGAGTGGTgtgacatgcaagtaaatgttccacagcaggctctggccaggggagggcattatttgtagcattcacctatt
Downstream sequence
tctgtggtgtaaatactcccactgtggccaatttcaagctaccaaagtgtcattactgaatacagagttggaaaaatgtgcacacaatcatttcttgcag
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate