Basic Information
VIS ID
TVIS10015224
Fusion event
HBV-chr20 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase
Start
2461
Orient
-
Integrated sequence
AGGTCCCCTAGAAGAAGAACTCCCTCGCCTCGCAGACGAAGGTCTCAATCGCCGCGTCGCAGAAGATCTCAATCTCGGGAATCTCAATGTTAGTATTCCT| |TGGACTCATAAGGTGGGGAACTTTACTGGGCTTTATTCTTCTACTGTACCTGTCTTTAATCCTCATTGGAAAACACCATCTTTTCCTAATATACATTTAC
Host Sequence
Chromosome
chr20
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
16043303/16062658 (Hg38)
End
16043303/16062658 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-103a-2/Upstream/5412963; hsa-mir-1-1/Downstream/2407957;
Nearest TSS
ENST00000382410/Upstream/76870; ENST00000616572/Downstream/307978;
Nearest CpG islands
None/Target, chr20-CpG: 39/Upstream/2066236, chr20-CpG: 50/Downstream/510533
Nearby gene
MACROD2(No orient, 9461)
Upstream sequence
aacatctgggtttaaatctcagctccatagtttaccagctgacttaacctctccaagactctgctgtcacatctctaaaatactgatgatcattatttat
Downstream sequence
cacttacgattttaataaaggtaaattttatacacacacacattgcttagcatacagaaaaaatgatggttaattattTTTATGAGAAAGAGGTATCTGA
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
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