Basic Information
VIS ID
TVIS10015236
Fusion event
HBV-chr18 integration
Validated
No
Detection method
WGS
Data source
Curated
Sample type
Tumor
Disease
Hepatocellular carcinoma (HCC)
Quality evaluation
Normal
Reported year
2012
PubMed ID
22634754
Virus Sequence
Virus name
HBV
Reference genome
NC_003977
Region type
HBVgp1 Polymerase;HBVgp2 pre-S2/S
Start
33
Orient
+
Integrated sequence
AATTCCACAACCTTCCACCAAACTCTGCAAGAT| |CCCAGAGTGAGAGGCCTGTATTTCCCTGCTGGTGGCTCCAGTTCAGGAACAGTAAACCCTGTTCTGACTACTGCCTCTCCCTTATCGTCAATCTTCTCGA
Host Sequence
Chromosome
chr18
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
72836752/75124796 (Hg38)
End
72836752/75124796 (Hg38)
Orient
-
Location type
Intergenic
Nearest miRNA
hsa-mir-1-2/Upstream/2271414;
Nearest TSS
ENST00000575820/Upstream/51253; ENST00000560661/Downstream/80717;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/36805, chr18-CpG: 111/Downstream/79356
Upstream sequence
TGGTAATCACTGGAGGGCTCTGTCCATCACTCCAGGGCCTGTGCCTGCACTCGGTGCACAAGGGGGCCCTTTGGCCTTCTCCACGCTTTGTGACAGAGAT
Downstream sequence
AAGGGTGCACGGAGACGACTGAGGGAAATGGCAACATGATTTTTAAACACTAAGAATGAAGAGAAGCGATTACGGGATGCACGTGGCCCTCATGGGCCTT
Reference
Sung, W. K., et al. Genome-wide survey of recurrent HBV integration in hepatocellular carcinoma. Nat Genet,2012, 44(7): 765-769.
Curate